Table 1

Resting membrane potential, input resistance and hyperpolarizing effects of morphine (0.1 μM) in S cells from guinea pigs implanted with placebo or morphine pellets

PretreatmentResting Em (mV)Resistance (MΩ)Morphine Effects
Hyperpolariz (mV)Δ Resistance (MΩ)
Placebo−46.8  ± 0.8113.1  ± 12.26.6  ± 0.5−26.1  ± 7.9
Morphine−39.6  ± 1.5* 102.7  ± 8.65.8  ± 0.8−17.1  ± 4.3
  • Values are means of 18 placebo cells and 28 cells from morphine-pretreated guinea pigs.

  • * P < .05.