Table 1

Alpha Adrenergic receptor affinities and selectivities of besipirdine, P7480 and idazoxan; affinity values represent the mean and S.E.M. of three to four determinations; all binding experiments were performed in rat cortical membranes (for details see “Materials and Methods”)

KI (μM)
BesipirdineP7480Idazoxan
Alpha-1 Adrenoceptor:5.66  ± 0.991.49  ± 0.390.77  ± 0.07
Alpha-2 Adrenoceptor:0.38  ± 0.040.018  ± 0.0060.005  ± 0.002
α12ratio:1583154