Mean (± S.E.M.) codeine and codeine metabolites pharmacokinetics before and after the administration of rifampin in PMs
| Compound | T½(h) | AUC0→∞ (nM·h) | Renal Clearance (ml/min) | |||
|---|---|---|---|---|---|---|
| Before | After | Before | After | Before | After | |
| NC | 6.56 | 3.26 | 1388 | 1888 | 213.2 | 246.6 |
| (1.50) | (0.422-a) | (327) | (372) | (18.6) | (37.1) | |
| NCG | 5.61 | 4.49 | 1534 | 3075 | 103.5 | 123.8 |
| (1.07) | (1.072-a) | (192) | (6432-a) | (38.5) | (22.9) | |
| C6G | 3.01 | 2.04 | 42516 | 26382 | 87.2 | 86.0 |
| (0.18) | (0.242-b) | (4557) | (21792-b) | (4.79) | (7.8) | |
| COD | 2.93 | 1.47 | 3072 | 578 | 51.8 | 35.5 |
| (0.23) | (0.312-c) | (489) | (1552-c) | (10.0) | (22.8) | |