Effect of BMS-180448 with or without glyburide on postischemic cardiac function and coronary flow in isolated rat hearts
| Predrug | Reperfusion 30 min | |
|---|---|---|
| HR (bpm) | ||
| Vehicle | 282 ± 7 | 210 ± 52-a |
| 10 μM BMS (reper only) | 290 ± 12 | 286 ± 92-b |
| 1 μM GLY (reper only) | 274 ± 9 | 215 ± 252-a |
| 10 μM BMS + 1 μM GLY (reper only) | 275 ± 10 | 218 ± 202-a |
| 10 μM BMS (pre/postisch) | 286 ± 7 | 276 ± 92-b |
| 10 μM BMS + 1 μM GLY (pre/postisch) | 280 ± 6 | 217 ± 232-a |
| LVDP (mm Hg) | ||
| Vehicle | 130 ± 10 | 18 ± 32-a |
| 10 μM BMS (reper only) | 129 ± 6 | 38 ± 3a,b |
| 1 μM GLY (reper only) | 134 ± 5 | 16 ± 52-a |
| 10 μM BMS + 1 μM GLY (reper only) | 130 ± 5 | 21 ± 42-a |
| 10 μM BMS (pre/postisch) | 137 ± 5 | 85 ± 6a,b |
| 10 μM BMS + 1 μM GLY (pre/postisch) | 135 ± 5 | 15 ± 32-a |
| Coronary flow (ml/min/g) | ||
| Vehicle | 18.6 ± 1.0 | 12.8 ± 1.12-a |
| 10 μM BMS (reper only) | 18.1 ± 0.5 | 14.7 ± 1.12-a |
| 1 μM GLY (reper only) | 18.2 ± 0.6 | 8.3 ± 0.62-a |
| 10 μM BMS + 1 μM GLY (reper only) | 19.9 ± 1.2 | 14.1 ± 0.92-a |
| 10 μM BMS (pre/postisch) | 19.8 ± 2.7 | 18.2 ± 1.92-b |
| 10 μM BMS + 1 μM GLY (pre/postisch) | 19.3 ± 3.6 | 11.6 ± 1.02-a |
All values are mean ± S.E.M.; BMS, BMS-180448; GLY, glyburide; reper only, treatment only during reperfusion; pre/postisch, treatment both before and after ischemia.
↵2-a Significantly different from its respective predrug value (P < .05).
↵2-b Significantly different from its respective vehicle group value (P < .05).