Effect of P-glycoprotein substrates on ATP-dependent, ditekiren uptake by canalicular membrane vesicles
| Substrate | ATP-dependent initial uptake rate | Inhibition | |
|---|---|---|---|
| Control | P-glycoprotein substrate | ||
| pmol/mg of protein/15 sec | % | ||
| Cyclosporin A | 8.06 ± 2.22 | 1.02 ± 1.93 | 86.72-b |
| Nicardipine | 8.06 ± 2.22 | 2.28 ± 1.37 | 85.62-a |
| Daunomycin | 6.96 ± 1.02 | 2.30 ± 1.23 | 65.92-b |
| Verapamil | 6.83 ± 1.64 | 2.22 ± 0.43 | 65.32-b |
| Reserpine | 8.19 ± 1.99 | 2.39 ± 0.98 | 60.32-b |
| Rhodamine -123 | 8.99 ± 1.78 | 4.67 ± 1.55 | 46.42-b |
| Vinblastine | 6.30 ± 1.06 | 3.84 ± 0.99 | 42.42-a |