Table 1

Effect of other oligopeptides on ATP-dependent, ditekiren transport by canalicular membrane vesicles

PeptideATP-dependent initial uptake rateInhibition
ControlOligopeptide
pmol/mg of protein/15 sec %
EMD-550688.06  ± 2.220.87  ± 0.6080.41-a
EMD-519216.96  ± 0.852.59  ± 0.8461.51-a
Angiopeptin9.09  ± 1.673.77  ± 1.4261.21-a
U-710138.97  ± 1.344.74  ± 2.3837.5
U-774368.24  ± 1.687.56  ± 1.4315.4
  • Values are mean ± S.E.M. for five separate membrane preparations.

  • 1-a P < .05.