Table 2

Mean ± S.D. pharmacokinetic parameters for remifentanil, GR90291 and alfentanil in anesthetized dogs

Pharmacokinetic ParameterRemifentanil (n = 7)GR90291 (n = 8)Alfentanil (n = 9)
V c(ml/kg)2-a 117  ± 60135  ± 60132  ± 41
V SS (ml/kg)222  ± 102293  ± 130558  ± 230
CL(ml/min/kg)63.1  ± 18.110.6  ± 3.9029.8  ± 14.5
T1/2β (min)2-b 5.59  ± 0.6219.2  ± 9.6319.9  ± 9.21
k 10(min−1)0.5856  ± 0.14810.0853  ± 0.03240.2235  ± 0.0663
k 12(min−1)0.1569  ± 0.04670.1761  ± 0.07900.2076  ± 0.0563
k 21(min−1)0.1676  ± 0.02190.1412  ± 0.07310.0711  ± 0.0243

  • ↵2-a V c, central compartment volume;V SS, steady-state volume of distribution;CL, clearance.

  • ↵2-b Values expressed as harmonic mean and jackknife S.D. (Lamet al., 1985).