Effect of pretreatment drugs on BP after i.t. or i.c. injection in urethane-anesthetized rats
| Drug dose (nmol) | BP (mm Hg) | ||
|---|---|---|---|
| Base line | 10 min after pretreatment | Immediately before carbachol | |
| Saline | 90.6 ± 3.0 | 90.5 ± 3.8 | 88.8 ± 3.2 |
| D-AP7 (10, i.t.) | 83.4 ± 4.8 | 66.4 ± 2.2ab | 69.2 ± 2.0ab |
| D-AP7 (100, i.t.) | 85.4 ± 3.5 | 60.8 ± 4.6ab | 61.4 ± 4.5ab |
| D-AP7 (1000, i.t.) | 87.4 ± 4.0 | 66.2 ± 1.6ab | 68.2 ± 2.3ab |
| D-AP7 (100, i.c.) | 93.4 ± 1.8 | 105 ± 2.5ab | 103 ± 6.42-b |
| MK801 (10, i.t.) | 93.8 ± 5.4 | 86.7 ± 5.3 | 86.6 ± 5.3 |
| MK801 (100, i.t.) | 97.1 ± 1.7 | 81.0 ± 1.62-a | 90.3 ± 2.4 |
| MK801 (1000, i.t.) | 88.5 ± 4.6 | 62.9 ± 2.0ab | 83.7 ± 2.7 |
| DMSO/saline | 90.8 ± 5.4 | 94.8 ± 1.7 | 92.2 ± 4.6 |
| CNQX (10, i.t.) | 97.4 ± 3.8 | 86.8 ± 4.5 | 88 ± 4.7 |
| CNQX (100, i.t.) | 92.5 ± 4.0 | 83.7 ± 2.7 | 83.1 ± 2.4 |
Each value represents the mean ± S.E.M.
↵2-a Significantly different, P < .05 (two-tailed), from base line within the same row (within groups).
↵2-b Significantly different from the respective saline value within the same column (between groups) (n = 4–6 animals/experimental group).
One saline control was run with each group for a total of 11 controls.