Effects of seratrodast and azelastine on the antigen-induced decrease in the area of the nasopharyngeal airway in actively sensitized guinea pigs
| Compound | No. of Animals | Area of Nasopharyngeal Airway (mm2) | Decrease in Area (%) | Inhibition (%) |
|---|---|---|---|---|
| Experiment 1 | ||||
| Saline | 8 | 85.1 ± 6.7 | — | |
| OA | ||||
| Control | 8 | 56.6 ± 3.1** | 33 | — |
| Seratrodast | 8 | 70.2 ± 4.9† | 18 | 48 |
| Experiment 2 | ||||
| Saline | 7 | 90.4 ± 6.9 | — | |
| OA | ||||
| Control | 6 | 61.7 ± 6.5* | 32 | — |
| Azelastine | 7 | 80.8 ± 5.2† | 11 | 67 |
Actively sensitized guinea pigs were challenged by instillation of 0.3% OA into the nasal cavity. Seratrodast (30 mg/kg), azelastine (1 mg/kg) or 5% gum arabic (control) was administered p.o. 1 hr before antigen challenge. Each value represents the mean ± S.E. for 6 to 8 animals.
* P < .05, ** P < .01 compared with the saline-challenged group (unpaired t test). † P < .05 compared with the OA-challenged control group (unpaired ttest).