EC50, Emax and slope for 5-HT elicited decrease in sAHP amplitude in CA1 hippocampal pyramidal cells from control and fluoxetine-treated rats4-a
| Drug | CA1 | ||
|---|---|---|---|
| EC50(−log) | Emax % decrease | Slope | |
| Control | 5.48 ± 0.09 (8) | 50.81 ± 4.23 (8) | 2.57 ± 0.34 (8) |
| Fluoxetine | 5.78 ± 0.13 (7) | 57.69 ± 8.97 (8) | 2.19 ± 0.33 (8) |
↵4-a E max values are the percent inhibition of the sAHP amplitude as compared with the base-line sAHP amplitude. Estimates were obtained by fitting concentration-response data from individual cells to the formula for a logistic/hyperbolic function. Values listed are the mean ± S.E.M., and the numbers of cells tested are given in parentheses.