EC50, Emax and slope values for 5-HT-elicited hyperpolarization in CA1 and CA3 hippocampal pyramidal cells from control and fluoxetine-treated rats2-a
| Treatment | CA1 | CA3 | ||||
|---|---|---|---|---|---|---|
| EC502-b (−log) | Emax2-c(mV) | Slope2-d | EC50(−log) | Emax (mV) | Slope | |
| Control | 5.29 ± 0.04 (11) | 11.62 ± 0.95 (11) | 2.21 ± 0.21 (11) | 4.94 ± 0.09 (7) | 18.51 ± 1.77 (7) | 2.04 ± 0.23 (7) |
| Fluoxetine | 5.64 ± 0.10 (11) | 11.24 ± 0.88 (11) | 1.42 ± 0.12 (11) | 5.00 ± 0.13 (7) | 18.79 ± 1.91 (7) | 1.73 ± 0.28 (7) |
↵2-a Estimates were obtained by fitting concentration-response data from individual cells to the formula for a logistic/hyperbolic function. Values listed are the mean ± S.E.M., and the numbers of cells tested are given in parentheses.
↵2-b CA1 control different from CA3 control, F = 14.97, P = .0014; CA1 control different from CA1 fluoxetine,F = 11.05, P = .0034.
↵2-c CA1 control different from CA3 control, F = 14.06, P = .0017.
↵2-d CA1 control different from CA1 fluoxetine, F= 10.29, P = .0044.