Table 4
Ganaxolone potentiation of GABA-evoked currents from human recombinant GABA
A
receptors
α1β1γ2
L
α2β1γ2
L
α3β1γ2
L
EC
50
(nM)
213 ± 14
94 ± 6
122 ± 9
E
max
(% of GABA maximum)
70 ± 9
74 ± 5
69 ± 1
Hill coefficient
1.2 ± 0.1
1.3 ± 0.1
1.1 ± 0.1