Effect of SDZ HTF 919 on gastric emptying (by linear analysis) and small bowel transit time (SBTT)
| Gastric Emptying | SBTT | ||
|---|---|---|---|
| Lag Duration | Post-Lag Fractional Emptying Rate | ||
| min | %/min | min | |
| Saline | 65 ± 15 | 0.36 ± 0.05 | 67 ± 8 |
| Vehicle | 64 ± 28 | 0.27 ± 0.02 | 75 ± 22 |
| SDZ HTF 919, 0.03 mg/kg | 32 ± 6 | 0.55 ± 0.16 | 52 ± 12 |
| SDZ HTF 919, 0.10 mg/kg | 36 ± 6 | 0.32 ± 0.04 | 69 ± 13 |
| SDZ HTF 919, 0.30 mg/kg | 35 ± 7 | 0.53 ± 0.16 | 45 ± 9* † |
Data show mean ± S.E.M.
* P < .1 vs. vehicle.
† P < .05 vs. .1 mg/kg dose.