Table 6

Effects of TAK-147 and tacrine on monoamine metabolism in the rat brain

Regions	Treatment (mg/kg p.o.)	MHPG	DOPAC + HVA	5-HIAA
Regions	Treatment (mg/kg p.o.)	NE	DA	5-HT
C. Cortex	Saline control	0.074 ± 0.005	0.261 ± 0.008	0.140 ± 0.008
	TAK-147 3	0.073 ± 0.003	0.305 ± 0.026	0.177 ± 0.013^6-a
	Tacrine 3	0.069 ± 0.004	0.348 ± 0.045	0.187 ± 0.012^b

Hippocampus	Saline control	0.038 ± 0.002	0.151 ± 0.021	0.136 ± 0.013
	TAK-147 3	0.050 ± 0.004^6-a	0.234 ± 0.022^6-a	0.170 ± 0.014
	Tacrine 3	0.047 ± 0.003^6-a	0.221 ± 0.013^6-a	0.256 ± 0.016^c

Striatum	Saline control	0.060 ± 0.003	0.174 ± 0.009	0.102 ± 0.009
	TAK-147 3	0.077 ± 0.005^b	0.193 ± 0.004	0.157 ± 0.022
	Tacrine 3	0.073 ± 0.003^b	0.194 ± 0.010	0.155 ± 0.025

Diencephalon	Saline control	0.020 ± 0.001	0.329 ± 0.031	0.173 ± 0.027
	TAK-147 3	0.021 ± 0.003	0.430 ± 0.024^6-a	0.376 ± 0.042^b
	Tacrine 3	0.020 ± 0.001	0.405 ± 0.058	0.227 ± 0.026

Brain stem	Saline control	0.070 ± 0.003	1.144 ± 0.081	0.268 ± 0.019
	TAK-147 3	0.079 ± 0.003	1.086 ± 0.054	0.298 ± 0.024
	Tacrine 3	0.068 ± 0.003	0.940 ± 0.066	0.357 ± 0.048

Each value represents the mean of eight animals with the S.E.M.
↵6-a P < .05, ^b P < .01, ^c P < .001, compared with the saline control group (Student’st test).