Effects of TAK-147, tacrine and physostigmine on monoamine receptor binding in the rat brain
| Compound | Monoamine Receptor Binding Inhibition (Ki : nM) | |||||
|---|---|---|---|---|---|---|
| α1 | α2 | D1 | D2 | 5-HT1A | 5-HT2 | |
| TAK-147 | 324 | 2330 | 27200 | 12400 | 6690 | 3510 |
| Tacrine | 220 | 5130 | N.E. | N.E. | 9930 | 14700 |
| Physostigmine | N.E.5-a | N.E. | N.E. | N.E. | N.E. | N.E. |
Each value represents the mean of two or three determinations done in triplicate.
↵5-a N.E., IC50 value is more than 100 μM.