Effects of TAK-147, tacrine and physostigmine on muscarinic ACh receptor binding in the rat brain
| Compound | ACh Receptor Binding Inhibition (Ki : nM) | |
|---|---|---|
| Muscarinic M1 | Muscarinic M2 | |
| TAK-147 | 234 ± 43 | 340 ± 53 |
| Tacrine | 264 ± 31 | 598 ± 53 |
| Physostigmine | 8940 ± 840 | 14700 ± 6500 |
Each value represents the mean with the S.E.M. of three to four determinations done in triplicate.