Effects of TAK-147, tacrine and physostigmine on AChE activity in the rat cerebral cortex and BuChE activity in the rat plasma
| Compound | AChE Inhibition (IC50: nM) | BuChE Inhibition (IC50: nM) | Selectivity (BuChE/AChE) |
|---|---|---|---|
| TAK-147 | 51.2 ± 4.0 | 23500 ± 4500 | 459 |
| Tacrine | 153 ± 12 | 53.8 ± 9.3 | 0.38 |
| Physostigmine | 125 ± 17 | 14.9 ± 1.5 | 0.12 |
Each IC50 value to AChE and BuChE activities represents the mean with the S.E.M. of four and three determinations done in triplicate, respectively.