Effect of xanthine and xanthine analogs
| + Glucose 8 mM + AMP 0.3 mM | + Glucose 20 mM + AMP 0.3 mM | + Combination 1 | + Combination 2 | |||||
|---|---|---|---|---|---|---|---|---|
| 1 mM Pi | 5 mM Pi | 1 mM Pi | 5 mM Pi | 1 mM Pi | 5 mM Pi | 1 mM Pi | 5 mM Pi | |
| No addition2-a | 163 ± 2 | 119 ± 9 | 152 ± 1 | 120 ± 4 | 100 ± 7 | 102 ± 5 | 98 ± 6 | 92 ± 4 |
| Caffeine (1 mM) | 91 ± 3 | 96 ± 2 | 53 ± 2 | 76 ± 2 | 38 ± 1 | 55 ± 2 | 16 ± 1 | 29 ± 1 |
| Adenosine (1 mM) | 150 ± 4 | 117 ± 5 | 100 ± 3 | 89 ± 3 | 80 ± 4 | 73 ± 4 | 65 ± 2 | 54 ± 3 |
| Theophylline (1 mM) | 95 ± 5 | 102 ± 6 | 70 ± 3 | 88 ± 3 | 64 ± 2 | 78 ± 2 | 53 ± 3 | 63 ± 4 |
| Xanthine (1 mM) | 38 ± 3 | 37 ± 1 | 37 ± 4 | 39 ± 2 | 40 ± 3 | 37 ± 1 | 40 ± 3 | 39 ± 4 |
| Hypoxanthine (1 mM) | 35 ± 5 | 25 ± 3 | 26 ± 3 | 20 ± 3 | 42 ± 3 | 31 ± 2 | 27 ± 3 | 22 ± 2 |
| 3-Methylxanthine (1 mM) | 31 ± 5 | 25 ± 3 | 22 ± 1 | 20 ± 2 | 28 ± 1 | 25 ± 2 | 27 ± 2 | 23 ± 2 |
| Azaxanthine (1 mM) | 28 ± 2 | 26 ± 3 | 30 ± 3 | 25 ± 1 | 31 ± 1 | 27 ± 3 | 33 ± 2 | 28 ± 3 |
| 1-Methylxanthine (1 mM) | 58 ± 4 | 32 ± 3 | 42 ± 4 | 27 ± 2 | 41 ± 3 | 25 ± 1 | 40 ± 3 | 29 ± 1 |
| 7-Methylxanthine (1 mM) | 40 ± 3 | 22 ± 1 | 36 ± 3 | 21 ± 2 | 21 ± 2 | 29 ± 2 | 21 ± 1 | 28 ± 2 |
Data are presented as % of activity in the absence of any effectors.
↵2-a No addition refers to relative activity in the absence of caffeine or its analogs; n = 5 or more for each effector.