Table 1

Effects of nucleoside analogs on mtDNA content in NGF-primed PC-12 cells

Compound	Concentration	Ratio to Control of mtDNA Synthesis^1-a	P^1-c
	μM	%
AZT	25	101.5 ± 14.8^1-b	>.05
3TC	10	104.7 ± 2.6	>.05
ddI	0.5	93.0 ± 22.6	>.05
	5	65.6 ± 12.6	<.01
	10	54.1 ± 1.8	<.01
ddC	10	21.5 ± 12.6	<.01
d4T	10	106.4 ± 11.2	>.05

↵1-a Cells were continuously exposed for 7 days to drugs in poly-l-lysine-coated cell culture clusters.
↵1-b Mean ± S.D. of three experiments.
↵1-c The t test was performed for all nucleoside analogs compared with control, and the degree of freedom was 4.