Kinetic parameters for uptake of E3040 glucuronide or sulfate by isolated rat hepatocytes
| Km | Vmax | Pdif | Vmax/Km | |
|---|---|---|---|---|
| μM | nmol/min/106cells | μl/min/106 cells | μl/min/106 cells | |
| E3040 glucuronide | 59.2 ± 13.1 | 2.21 ± 0.87 | 4.31 ± 0.03 | 36.7 ± 8.7 |
| E3040 sulfate | 24.7 ± 1.94 | 7.75 ± 1.94 | 7.20 ± 2.09 | 313 ± 3 |
The data shown in figure 5 were analyzed to determine the kinetic parameters by use of equation 2.