E3040 Glucuronide | E3040 Sulfate | |
---|---|---|
AUC∞ (% dose · min/ml) | 5.74 ± 1.04 | 18.9 ± 0.1 |
CLtot (ml/min/kg) | 56.3 ± 11.2 | 19.7 ± 0.5 |
Vdss (ml/kg) | 643 ± 102 | 593 ± 72 |
Xbile (% dose) | 94.6 ± 0.9 | 59.2 ± 8.2 |
Xurine (% dose) | 5.20 ± 1.74 | 20.6 ± 5.4 |
CLbile (ml/min/kg) | 53.5 ± 11.5 | 11.6 ± 1.6 |
CLrenal (ml/min/kg) | 2.75 ± 0.83 | 3.89 ± 1.06 |
CLu,renal (ml/min/kg) | 7.17 ± 2.19 | 63.8 ± 17.4 |
The values were calculated from the data shown in figures 1 and 2. CLbile and CLrenal were calculated by dividing the amount of conjugates excreted into the bile and the urine by the AUC∞ value. CLu,renal was calculated by dividing CLrenal by the respective unbound fraction of each conjugate (glucuronide, 0.379; sulfate, 0.0613). All values are given as the mean ± S.E. of three different experiments.