Characteristics of the 14 human livers
| Number | R/S ratio | Putative Phenotype | Used for |
|---|---|---|---|
| HL-3 | 0.075 | EM | Kinetic study1-a |
| HL-6 | 0.162 | EM | Kinetica,b, correlation and inhibition studies |
| HL-8 | 0.886 | PM | Kinetica,b, correlation and inhibition studies |
| HL-26 | 0.198 | EM | Kinetic study1-a |
| HL-29 | 0.793 | PM | Kinetica,b, inhibition and immunoinhibition studies |
| HL-2 | 0.115 | EM | Correlation and inhibition studies |
| HL-27 | 0.142 | EM | Inhibition study |
| HL-22 | 0.882 | PM | Kinetic1-b, correlation and inhibition studies |
| HL-5 | 0.204 | EM | Kinetic1-b, correlation and immunoinhibition studies |
| HL-30 | 0.153 | EM | Kinetic1-b, and correlation studies |
| HL-31 | 0.523 | EM | Correlation study |
| HL-32 | 0.749 | PM | Correlation study |
| HL-33 | 0.104 | EM | Correlation study |
| HL-34 | 0.058 | EM | Correlation study |
The R/S ratio was determined as the ratio of the rate of formation of 4′-hydroxymephenytoin with 1 mM (R)-mephenytoin to that with 1 mM (S)-mephenytoin. Microsomal samples with a ratio of >0.7 were classified as those derived from the putative PM patients.