Table 2

Effects of S6c on systemic and renal hemodynamics, and urine formation

MAP (mm Hg)HR (beats/min)RBF (ml/g/min)RVR (mm Hg/ml/ g/min)GFR (ml/g/min)FF (%)UF (μl/g/min)UNaV (μEq/g/min)FENa(%)
Saline infusion
 First
  Control136.8  ± 8.6148.8  ± 14.53.8  ± 0.740.5  ± 9.30.86  ± 0.0842.4  ± 11.212.7  ± 2.93.61  ± 0.582.8  ± 0.4
  Experiment (without RNS)135.5  ± 8.6150.0  ± 13.63.8  ± 0.740.0  ± 8.90.86  ± 0.0141.2  ± 8.212.6  ± 2.73.67  ± 0.522.9  ± 0.4
 Second
  Control135.0  ± 8.4148.0  ± 14.93.8  ± 0.739.3  ± 8.10.84  ± 0.0338.6  ± 7.213.5  ± 3.93.85  ± 0.903.0  ± 0.6
  Experiment (without RNS)133.5  ± 7.9149.0  ± 14.63.9  ± 0.738.1  ± 7.70.86  ± 0.0438.4  ± 6.114.5  ± 3.63.99  ± 0.823.1  ± 0.6
S6c infusion
 Third
  Control133.8  ± 6.6151.3  ± 9.33.6  ± 0.639.8  ± 6.20.83  ± 0.0738.3  ± 5.040.4  ± 8.4c 4.68  ± 0.563.8  ± 0.4
  Experiment (without RNS)133.8  ± 7.7152.8  ± 9.43.4  ± 0.6b 42.8  ± 6.8a 0.83  ± 0.0541.4  ± 5.743.7  ± 10.64.66  ± 0.633.7  ± 0.4
 Fourth
  Control137.0  ± 10.5157.0  ± 12.33.7  ± 0.640.6  ± 7.30.88  ± 0.0640.1  ± 5.740.9  ± 9.2d 4.85  ± 1.023.7  ± 0.7
  Experiment (without RNS)137.8  ± 10.7159.8  ± 13.23.4  ± 0.5a 43.6  ± 7.8a 0.83  ± 0.0840.9  ± 5.441.4  ± 9.04.76  ± 0.944.0  ± 0.7
  • Each value represents the mean ± S.E. of four dogs. Effects of S6c in 3rd and 4th experimental condition were examined by Student’s t test: a P < .05,b P < .01, compared with each control value. Effects of S6c on basal renal function were examined by Bonferroni’s multiple comparison test: c P < .01 vs. control value in first experiment and d P < .01 vs. control value in second experiment during saline infusion.