Effect of ISIS 3082 on whole-body and organ weights. CD-1 mice were treated with the indicated dosage of ISIS 3082 every other day for a total of 14 days by i.v. injection. Selected organs were excised, trimmed of fat and connective tissue and weighed. Values represent the mean ± S.E.M. of five mice per group.
| Weight of | Sex | Dosage | |||
|---|---|---|---|---|---|
| 0 mg/kg | 1 mg/kg | 10 mg/kg | 100 mg/kg | ||
| Whole body (g) | Male | 31.6 ± 0.9 | 31.6 ± 1.5 | 30.8 ± 2.6 | 31.2 ± 1.1 |
| Female | 26.0 ± 0.7 | 26.2 ± 1.1 | 26.6 ± 1.5 | 26.4 ± 0.5 | |
| Liver (g) | Male | 1.696 ± 0.082 | 1.757 ± 0.232 | 1.644 ± 0.153 | 1.934 ± 0.191 |
| Female | 1.218 ± 0.082 | 1.289 ± 0.076 | 1.433 ± 0.064* | 1.650 ± 0.183* | |
| Spleen (g) | Male | 0.094 ± 0.007 | 0.102 ± 0.035 | 0.105 ± 0.018 | 0.128 ± 0.009* |
| Female | 0.111 ± 0.082 | 0.121 ± 0.015 | 0.131 ± 0.006 | 0.136 ± 0.037* | |
| Lung (g) | Male | 0.208 ± 0.041 | 0.218 ± 0.025 | 0.216 ± 0.030 | 0.213 ± 0.024 |
| Female | 0.194 ± 0.016 | 0.207 ± 0.027 | 0.223 ± 0.034 | 0.200 ± 0.019 | |
P < .05 compared with control.