The analysis of swimming paths of rats trained for 4 days in the Morris water maze and performing the probe trial (mean ± S.E.M.)
| Parameter | Pretreatment before learning-Treatment before probe trial | ANOVA F(2,21) | ||
|---|---|---|---|---|
| Placebo-Placebo | Placebo-Memantine | Memantine-Placebo | ||
| Time in the training quadrant (sec) | 21.2 ± 2.8 | 20.2 ± 2.0 | 23.2 ± 2.4 | <1 |
| Platform position hits | 3.1 ± 0.5 | 2.0 ± 0.8 | 1.6 ± 0.4 | 1.724 |
| Path (cm) | 1442 ± 53 | 1434 ± 54 | 1641 ± 63* | 4.24, P < .05 |
| Activity (sec) | 59.0 ± 0.2 | 58.4 ± 0.6 | 59.5 ± 0.2 | 2.07 |
| Mean distance to the wall (cm) | 28.3 ± 2.1 | 31.1 ± 3.0 | 25.1 ± 1.9 | 1.59 |
Rats (n = 8 in each group) were treated with [placebo + placebo], [placebo + memantine] or [memantine + placebo] before each of the four learning trials and before the probe trial, respectively. Memantine was used at the dose of 7.5 mg/kg.
* P < .05 vs. all other groups (Student-Newmann-Keuls test).