Tight segmental nerve ligation (Chung model)
| Drug | Motor Dysfunction | ED50Analgesia | Therapeutic Index | |||
|---|---|---|---|---|---|---|
| (MD) dose, μg | μg (95% CI) | MD/ED50 | ||||
| Ketamine | 200 | >100 | <2 | |||
| MK801 | 20 | >10 | <2 | |||
| Dextromethorphan | >250 | 115 (39–337) | >2.2 | |||
| Dextrorphan | 300 | 26 (7–94) | 11.7 | |||
| Memantine | >200 | 71 (43–115) | >2.8 | |||
| AP5 | 20 | 2 (1–5) | 11.8 | |||
| DNQX | 13 | 1 (.1–27) | 10.8 | |||
| 7CKU | >10 | 10 | >1 | |||
| AP3 | 20 | |||||
Summary of doses at which impairment of motor function was noted (motor dysfunction, MD), the ED50 for the allodynic effect was observed and the calculated therapeutic index, MD/ED50.