Affinity of P10358 at various receptors, uptake carriers and ion channels
| Receptor | IC50 (μM) | Receptor | IC50 (μM) |
|---|---|---|---|
| alpha-1 Adrenergic | >10 | 5-HT uptake | >10 |
| alpha-2 Adrenergic | >10 | NE uptake | >10 |
| D2-dopaminergic | >10 | DA uptake | >10 |
| Muscarinic | >10 | Adenosine uptake3-a | >10 |
| Nicotinic | >10 | Ca+ channel3-a | >10 |
| Adenosine A13-a | >1 | K+ ATPchannel3-a | >10 |
| Angiotensin II3-a | >10 | Endothelin-B3-a | >10 |
| Bradykinin3-a | >10 | 5-HT1A 3-a | >1 |
| NMDA3-a | >10 | 5-HT2A 3-a | >1 |
| Quisqualate3-a | >10 | GABAA 3-a | >10 |
| [Mu]-Opioid3-a | >10 |
↵3-a Hoechst central screening.