Effect of combined blockade of the neuronal and non-neuronal uptake systems on the potency of ISO and NE at right atrial beta-receptors mediating chronotropy
| Agonist/Treatment Group | pEC50 | Shift | N | |
|---|---|---|---|---|
| Preblockade | Postblockade1-a | |||
| ISO | ||||
| Naive | 8.53 ± 0.06 | 8.89 ± 0.08 | 2.3 ± 0.5 | 5 |
| Sham | 8.54 ± 0.07 | 8.72 ± 0.10 | 1.5 ± 0.1 | 5 |
| SAD | 8.19 ± 0.06 | 8.36 ± 0.04 | 1.5 ± 0.2 | 5 |
| NE | ||||
| Naive | 6.84 ± 0.05 | 7.45 ± 0.02 | 3.7 ± 0.7 | 6 |
| Sham | 6.56 ± 0.08 | 7.42 ± 0.08 | 6.5 ± 1.7 | 6 |
| SAD | 6.17 ± 0.18 | 6.91 ± 0.18 | 5.5 ± 0.8 | 5 |
↵1-a All postblockade pEC50 values are significantly different from their respective preblockade controls, P < .05, Student’s paired t test.
Data are mean ± S.E. for N experiments.