Parameters for the plasma-brain transport and the distribution in the brain of probenecid and salicylate in rats
| Parameters | Probenecid | Salicylate |
|---|---|---|
| CLin (ml/min/g brain) | 0.00733 ± 0.00218 | 0.00864 ± 0.00168 |
| CLout (ml/min/g brain) | 0.0373 ± 0.0052* | 0.0736 ± 0.0210* |
| keff(min−1) | 0.0179 ± 0.0010 | 0.0324 ± 0.0066 |
| Vd (ml/g brain) | 2.10 ± 0.39 | 2.30 ± 0.71 |
| CLcsf (ml/min/g brain) | 0.0221 ± 0.0034 | — |
Values represent the mean ± S.D. of 3 to 4 determinations.
* Significantly different from CLin (P < .05).