Table 1

Effect of bimakalim on pre- and postischemic cardiac function and coronary flow in isolated rat hearts

	Predrug	Postdrug	Reperfusion (30 min)
Heart rate (beats/min)
0 μM Bimakalim	272 ± 11	275 ± 8	272 ± 16
0.1 μM	293 ± 7	280 ± 12	253 ± 36
0.3 μM	298 ± 6	273 ± 2	293 ± 10
1.0 μM	271 ± 15	277 ± 22	268 ± 7
3.0 μM	289 ± 10	270 ± 9	287 ± 8
LVDP (mm Hg)
0 μM	126 ± 7	121 ± 5	17 ± 1^1-a
0.1 μM	131 ± 2	116 ± 2^1-a	23 ± 4^1-a
0.3 μM	134 ± 4	112 ± 4^1-a	40 ± 8^1-a ^, ^1-b
1.0 μM	134 ± 3	120 ± 4	58 ± 7^1-a ^, ^1-b
3.0 μM	135 ± 3	92 ± 3^1-a ^, ^1-b	80 ± 3^1-a ^, ^1-b
Coronary flow (ml/min/g)
0 μM	18.3 ± 1.2	17.7 ± 0.9	13.3 ± 0.8^1-a
0.1 μM	17.8 ± 0.2	24.1 ± 1.2^1-a ^, ^1-b	12.3 ± 1.1^1-a
0.3 μM	18.8 ± 0.5	24.5 ± 0.9^1-a ^, ^1-b	15.3 ± 1.8^1-a
1.0 μM	18.3 ± 0.7	24.3 ± 0.9^1-a ^, ^1-b	15.4 ± 0.4^1-a
3.0 μM	18.4 ± 1.1	26.6 ± 0.6^1-a ^, ^1-b	17.3 ± 0.7^1-a ^, ^1-b

All values are mean ± S.E.

↵1-a Significantly different from its respective predrug value (P < .05).
↵1-b Significantly different from its respective vehicle group value (P < .05).