Plasma | Milk | Ratio of Skim Milk to Whole Milk | Predicted Milk/Plasma Ratio | Observed Milk/Plasma Ratio | Ratio of Observed to Predicted | |||
---|---|---|---|---|---|---|---|---|
Un-ionized | Unbound | Un-ionized | Unbound | |||||
Nitrofurantoin | ||||||||
0.39 | 0.43 | 0.61 | 0.74 | 1.19 | 0.31 | 23.1 | ∼75 | |
Acidic (pKa = 7.2) | ||||||||
Solubility H2O = 190 μg/ml | ||||||||
Furazolidone | ||||||||
0 | 0.56 | 0 | 0.48 | 1.21 | 0.97 | 1 | ∼1 | |
Neutral | ||||||||
Solubility H2O = 40 μg/ml | ||||||||
Furaltadone | ||||||||
1 | 0.86 | 1 | 0.56 | 1.11 | 1.4 | 3.49 | ∼2.5 | |
Basic (pKa = 5.0) | ||||||||
Solubility H2O = 753 μg/ml |