Table 4

Effects of age, gender, and drug treatment on renal clearance of theophylline and formation clearance to theophylline metabolites

	Young Men (n = 8)	Young Women (n = 8)	Elderly Men (n = 8)	Elderly Women (n = 8)	P (Analysis of Variance)
	Young Men (n = 8)	Young Women (n = 8)	Elderly Men (n = 8)	Elderly Women (n = 8)	Age	Gender	Age × Gender
3MX
Base line	108.8 ± 14.7	93.4 ± 11.0	78.3 ± 9.5	58.8 ± 9.4	.008	NS	NS
Cimetidine	76.8 ± 12.7	55.4 ± 7.5	48.5 ± 7.3	31.4 ± 5.0	.005	.032	NS
Ciprofloxacin	59.9 ± 9.0	52.4 ± 8.7	44.5 ± 6.1	25.3 ± 4.3	.007	.074	NS
Cimetidine + ciprofloxacin	47.7 ± 6.5	38.8 ± 5.7	35.3 ± 5.9	19.0 ± 2.8	.006	.026	NS
P (analysis of variance)	.001	.001	.001	.001
1MU
Base line	131.4 ± 13.5	129.4 ± 22.7	97.1 ± 13.1	99.1 ± 11.9	.050	NS	NS
Cimetidine	97.1 ± 11.3	83.1 ± 16.9	65.5 ± 8.0	61.9 ± 5.2	.025	NS	NS
Ciprofloxacin	81.9 ± 12.5	73.8 ± 11.6	60.5 ± 6.8	52.4 ± 3.7	.029	NS	NS
Cimetidine + ciprofloxacin	70.4 ± 9.5	54.6 ± 8.6	49.5 ± 6.7	44.8 ± 4.9	.052	NS	NS
P (analysis of variance)	.001	.001	.001	.001
1,3DMU
Base line	186.5 ± 12.8	187.1 ± 13.1	160.7 ± 12.5	147.7 ± 10.2	.012	NS	NS
Cimetidine	144.8 ± 13.9	136.3 ± 12.0	119.4 ± 7.7	119.9 ± 5.1	.050	NS	NS
Ciprofloxacin	129.5 ± 8.9	133.1 ± 8.3	119.3 ± 8.4	114.9 ± 8.4	.105	NS	NS
Cimetidine + ciprofloxacin	123.0 ± 8.8	115.8 ± 10.1	103.4 ± 8.6	103.2 ± 6.5	.069	NS	NS
P (analysis of variance)	.001	.001	.001	.001
Theophylline
Base line	81.4 ± 9.8	94.2 ± 8.6	69.1 ± 9.0	79.1 ± 5.6	.109	NS	NS
Cimetidine	70.0 ± 9.7	81.0 ± 4.7	63.5 ± 7.2	75.9 ± 5.6	NS	.004	NS
Ciprofloxacin	69.3 ± 7.5	76.8 ± 5.3	62.0 ± 6.9	82.4 ± 7.1	NS	.046	NS
Cimetidine + ciprofloxacin	69.0 ± 6.3	71.8 ± 4.7	59.2 ± 8.4	74.4 ± 5.2	NS	NS	NS
P (analysis of variance)	.093	.003	.087	NS