AUC of cimetidine and ciprofloxacin administered alone and in combination
| Young | Elderly | P (Analysis of Variance) | |||||
|---|---|---|---|---|---|---|---|
| Men | Women | Men | Women | Age | Gender | Age × Gender | |
| Cimetidine (alone) (μg/hr/ml) | 5.34 ± 0.45 | 7.21 ± 0.71 | 8.40 ± 0.98 | 10.95 ± 1.30 | .011 | .040 | NS |
| Cimetidine (combined) (μg/hr/ml) | 5.07 ± 0.28 | 6.69 ± 0.53 | 8.50 ± 0.90 | 11.69 ± 1.63 | .011 | .007 | NS |
| Ciprofloxacin (alone) (μg/hr/ml) | 10.35 ± 0.86 | 12.97 ± 0.75 | 13.68 ± 0.74 | 19.28 ± 1.03 | .003 | .001 | NS |
| Ciprofloxacin (combined) (μg/hr/ml) | 10.75 ± 1.72 | 14.91 ± 0.81 | 15.96 ± 1.11 | 20.03 ± 1.54 | .005 | .008 | NS |
Values are mean ± S.E.M.