I.t. Pretreatment (3 hr) | I.t. Challenge | %MPE | n |
---|---|---|---|
None | (−)TAN-67 | 91.8 ± 5.6 | 14 |
(−)TAN-67 | (−)TAN-67 | 19.9 ± 15.2** | 8 |
DPDPE | (−)TAN-67 | 19.9 ± 8.2** | 8 |
[d-Ala2]deltorphin II | (−)TAN-67 | 79.5 ± 9.3 | 13 |
DAMGO | (−)TAN-67 | 86.4 ± 9.9 | 10 |
U50,488H | (−)TAN-67 | 94.7 ± 3.5 | 10 |
None | DPDPE | 86.0 ± 4.6 | 20 |
DPDPE | DPDPE | 31.7 ± 6.5** | 10 |
[d-Ala2]deltorphin II | DPDPE | 84.2 ± 8.4 | 8 |
TAN-67 | DPDPE | 6.8 ± 9.1** | 8 |
None | [d-Ala2]deltorphin II | 79.7 ± 6.5 | 10 |
[d-Ala2]deltorphin II | [d-Ala2]deltorphin II | 32.2 ± 6.2** | 10 |
DPDPE | [d-Ala2]deltorphin II | 67.7 ± 8.6 | 11 |
(−)TAN-67 | [d-Ala2]deltorphin II | 61.2 ± 5.3 | 23 |
None | DAMGO | 84.3 ± 5.8 | 10 |
DAMGO | DAMGO | 24.0 ± 4.6** | 10 |
(−)TAN-67 | DAMGO | 84.4 ± 7.4 | 10 |
None | U50,488H | 87.3 ± 7.8 | 10 |
U50,488H | U50,488H | 22.1 ± 5.7** | 9 |
(−)TAN-67 | U50,488H | 87.0 ± 8.3 | 9 |
The doses of the opioid agonists for the i.t. pretreatment and the i.t. challenge are (−)TAN-67, 89.4 nmol; DPDPE, 7.8 nmol; [d-Ala2]deltorphin II, 6.4 nmol; DAMGO, 19.5 pmol; U50,488H, 107.4 nmol.
** P < .01, compared with none treated control.