Effects of i.c. infusion of ATP on RSNA, MAP, HR and LVEDP in intact and vagotomized dogs (n = 7)
| Saline | 100 μg/kg/min | 200 μg/kg/min | 400 μg/kg/min | |||||
|---|---|---|---|---|---|---|---|---|
| Before | During | Before | During | Before | During | Before | During | |
| Intact group | ||||||||
| RSNA (%) | 100 ± 0 | 97 ± 3 | 96 ± 4 | 126 ± 7* | 98 ± 4 | 97 ± 8 | 101 ± 6 | 78 ± 11* |
| MAP (mm Hg) | 108 ± 6 | 107 ± 4 | 106 ± 3 | 94 ± 3* | 107 ± 4 | 81 ± 5* | 105 ± 4 | 76 ± 5* |
| HR (beats/min) | 111 ± 4 | 111 ± 5 | 111 ± 5 | 109 ± 5 | 109 ± 5 | 105 ± 6 | 109 ± 5 | 96 ± 6 |
| LVEDP (mm Hg) | 6.4 ± 0.3 | 6.2 ± 0.3 | 6.5 ± 0.3 | 5.7 ± 0.4 | 6.3 ± 0.3 | 4.9 ± 0.5 | 6.3 ± 0.4 | 4.9 ± 0.4 |
| Vagotomized group | ||||||||
| RSNA (%) | 100 ± 0 | 99 ± 2 | 101 ± 3 | 124 ± 5* | 99 ± 2 | 140 ± 5* | 101 ± 4 | 173 ± 12* |
| MAP (mm Hg) | 131 ± 3 | 131 ± 3 | 131 ± 3 | 125 ± 3 | 134 ± 3 | 122 ± 4* | 133 ± 2 | 114 ± 3* |
| HR (beats/min) | 120 ± 4 | 120 ± 4 | 119 ± 3 | 122 ± 4 | 121 ± 4 | 120 ± 3 | 120 ± 4 | 126 ± 4 |
| LVEDP (mm Hg) | 6.1 ± 0.5 | 6.1 ± 0.5 | 6.1 ± 0.4 | 5.9 ± 0.4 | 6.1 ± 0.5 | 6.0 ± 0.5 | 6.1 ± 0.4 | 6.3 ± 0.5 |
Values are mean ± S.E.M.
* P < .05, compared with values before ATP infusion.