Specific 3H-spiperone binding after 8 mo treatment with typical and atypical antipsychotics
| Control | Haloperidol (1.5 mg/kg/day) | Raclopride (10 mg/kg/day) | Clozapine (25 mg/kg/day) | |
|---|---|---|---|---|
| Caudate-putamen | ||||
| Medial part | 75.5 ± 3.9 | 106.9 ± 5.32-a | 90.7 ± 3.92-a | 74.8 ± 3.7 |
| (+42%) | (+20%) | |||
| Lateral part | 96.8 ± 4.1 | 134.1 ± 5.82-a | 114.0 ± 4.02-a | 95.3 ± 4.3 |
| (+39%) | (+18%) | |||
| Cortex | ||||
| Dorsolateral frontal | 17.5 ± 1.2 | 9.2 ± 0.82-a | 13.7 ± 1.32-a | 9.6 ± 0.92-a |
| (−48%) | (−22%) | (−45%) | ||
| Medial prefrontal | 19.7 ± 1.2 | 12.8 ± 1.22-a | 16.2 ± 1.2 | 11.0 ± 0.82-a |
| (−35%) | (−45%) | |||
| Hippocampus | 8.8 ± 0.9 | 9.1 ± 1.6 | 8.2 ± 0.5 | 8.7 ± 1.1 |
| Nucleus accumbens | 75.6 ± 2.1 | 110.9 ± 5.12-a | 90.3 ± 2.12-a | 71.5 ± 3.8 |
| (+47%) | (+19%) | |||
| Olfactory tubercle | 77.2 ± 1.9 | 79.4 ± 4.2 | 81.3 ± 4.5 | 82.0 ± 4.4 |
| Substantia nigra | ||||
| Pars compacta | 15.9 ± 1.3 | 27.4 ± 0.42-a | 22.0 ± 1.22-a | 16.0 ± 1.7 |
| (+72%) | (+38%) | |||
| Pars reticulata | 8.9 ± 0.7 | 15.0 ± 1.32-a | 13.2 ± 0.42-a | 9.2 ± 1.6 |
| (+69%) | (+48%) | |||
| Ventral tegmental area | 16.8 ± 0.6 | 18.4 ± 1.2 | 17.6 ± 1.5 | 14.0 ± 0.3 |
Data (mean ± S.E.M.) expressed in fmol/mg tissue,n = 6/group.
↵2-a Values significantly different from control (P < .05, Dunnett t test).