Specific 3H-nemonapride binding after 8 mo treatment with typical and atypical antipsychotics
| Control | Haloperidol (1.5 mg/kg/day) | Raclopride (10 mg/kg/day) | Clozapine (25 mg/kg/day) | |
|---|---|---|---|---|
| Caudate-putamen | ||||
| Medial part | 75.5 ± 3.8 | 118.2 ± 5.91-a | 99.9 ± 5.11-a | 85.3 ± 6.5 |
| (+57%) | (+32%) | |||
| Lateral part | 97.9 ± 5.2 | 147.0 ± 8.31-a | 128.1 ± 5.81-a | 109.2 ± 8.9 |
| (+50%) | (+31%) | |||
| Cortex | ||||
| Dorsolateral frontal | 7.0 ± 0.7 | 6.0 ± 0.8 | 8.9 ± 1.0 | 6.6 ± 0.7 |
| Medial prefrontal | 8.7 ± 0.8 | 8.5 ± 0.6 | 8.5 ± 0.4 | 9.3 ± 0.3 |
| Nucleus accumbens | 86.7 ± 4.4 | 152.2 ± 8.81-a | 116.1 ± 7.51-a | 95.2 ± 4.5 |
| (+75%) | (+34%) |
Data (mean ± S.E.M.) expressed in fmol/mg tissue,n = 6/group.
↵1-a Values significantly different from control (P < .05, Dunnett t test).