Table 1

Effects on GalN/SEB-induced inflammatory responses in mice by combined use of motapizone and rolipram^1-a

Pretreatment^1-b	ALT^1-c	AST^1-c	SDH^1-c	m/n^1-d	TNF^1-e	IL-10^1-e
	U/l			pg/ml
Solvent	5561 ± 2863	3125 ± 1340	5249 ± 2327	4 /12	341 ± 131	2730 ± 1122
Motapizone	6651 ± 3425	2938 ± 2037	4078 ± 1623	0 /6	164 ± 88^*	4235 ± 1412
Rolipram	4142 ± 1957	1607 ± 646	1593 ± 588	0 /6	156 ± 67^*	3979 ± 1011
Motapizone + rolipram	158 ± 98^*	134 ± 23^*	80 ± 38^*	0 /6	<10^*	8620 ± 372^*

↵1-a Data are mean values ± S.D. from two independent experiments performed on separate days with six (disease control) or three mice (all other groups). *P < .05 versus solvent control.
↵1-b GalN-sensitized (700 mg/kg i.p.) mice were pretreated with the PDE inhibitor(s) (0.1 mg/kg i.p.) or the corresponding volume of solvent 30 min before injection of SEB (2 mg/kg i.p.).
↵1-c Plasma enzyme activities were assessed 8 h after challenge.
↵1-d Survival was monitored (m = number of animals that died during the experiment, n = number of animals per group).
↵1-e Cytokines were determined 2.5 h after SEB injection in blood samples taken from the tail vein.