[3H]SCH-23390 binding and [3H]YM-09151-2 binding in the control, SIB(−) and SIB(+) groups
| [3H]SCH-23390 Binding (fmol/mg Tissue) | [3H]YM-09151-2 Binding (fmol/mg Tissue) | ||||||
|---|---|---|---|---|---|---|---|
| Control | SIB(−) | SIB(+) | Control | SIB(−) | SIB(+) | ||
| Dorsal striatum | |||||||
| Caudate-putamen rostral | CPDL | 396.2 ± 10.7 | 350.6 ± 16.2 | 353.2 ± 2.9 | 162.5 ± 5.3 | 169.1 ± 11.2 | 155.2 ± 14.7 |
| CPM | 373.4 ± 15.5 | 356.1 ± 11.4 | 357.6 ± 3.8 | 127.0 ± 2.6 | 109.3 ± 4.3 | 116.8 ± 11.4 | |
| CPVL | 398.9 ± 9.8 | 404.7 ± 14.2 | 400.7 ± 10.1 | 143.2 ± 3.6 | 143.8 ± 12.5 | 148.0 ± 10.9 | |
| CPPV | 346.4 ± 10.4 | 360.2 ± 3.9 | 346.8 ± 9.6 | 113.4 ± 7.5 | 137.2 ± 24.2 | 137.9 ± 14.3 | |
| Caudate-putamen central | CPDL | 363.7 ± 15.2 | 308.0 ± 28.8 | 346.8 ± 9.6 | 99.4 ± 9.4 | 123.4 ± 7.4 | 148.6 ± 14.2 |
| CPM | 361.6 ± 17.2 | 303.8 ± 27.0 | 365.3 ± 15.8 | 69.2 ± 7.1 | 78.0 ± 2.8 | 98.8 ± 9.6 | |
| CPVL | 406.6 ± 20.4 | 373.9 ± 22.6 | 402.1 ± 31.7 | 144.5 ± 21.5 | 163.0 ± 6.4 | 183.1 ± 12.1 | |
| CPPV | 406.3 ± 11.8 | 324.6 ± 28.2 | 344.6 ± 15.6 | 107.7 ± 8.1 | 106.9 ± 10.0 | 133.2 ± 7.7 | |
| Caudate-putamen caudal | 298.0 ± 10.2 | 297.6 ± 11.7 | 336.7 ± 15.6 | 89.0 ± 8.2 | 95.2 ± 7.7 | 100.7 ± 10.8 | |
| Ventral striatum | |||||||
| Nucleus accumbens | 375.1 ± 13.4 | 350.5 ± 22.1 | 398.7 ± 12.0 | 100.9 ± 8.1 | 92.4 ± 4.9 | 106.0 ± 12.2 | |
| Tuberculum olfactorium | 361.8 ± 25.2 | 345.6 ± 18.4 | 349.0 ± 4.7 | 104.1 ± 7.8 | 97.0 ± 5.5 | 84.4 ± 5.0 | |
| Midbrain | |||||||
| Substantia nigra pars compacta | 37.6 ± 3.6 | 13.7 ± 1.62-a | 8.2 ± 1.62-a | ||||
| Substantia nigra pars reticulata | 251.9 ± 11.0 | 287.2 ± 20.4 | 382.2 ± 23.7ab | ||||
| Ventral tegmental area | 17.2 ± 1.9 | 14.4 ± 0.9 | 12.5 ± 1.0 | 20.9 ± 3.0 | 14.1 ± 2.1 | 7.9 ± 1.32-a | |
| Other areas | |||||||
| Medial prefrontal cortex | 26.0 ± 0.9 | 26.7 ± 1.8 | 27.3 ± 2.1 | 20.4 ± 1.8 | 20.9 ± 2.1 | 20.4 ± 1.9 | |
| Anterior cingulate cortex | 25.7 ± 1.6 | 27.8 ± 1.3 | 28.7 ± 0.8 | 19.6 ± 1.3 | 18.1 ± 1.1 | 19.9 ± 1.0 | |
| Piriform cortex | 42.4 ± 2.1 | 47.7 ± 3.5 | 46.9 ± 3.5 | 14.8 ± 0.8 | 15.4 ± 1.5 | 13.7 ± 1.0 | |
| Entorhinal cortex | 43.6 ± 3.0 | 42.3 ± 2.5 | 47.4 ± 3.6 | 17.5 ± 1.0 | 16.6 ± 1.0 | 17.8 ± 1.8 | |
| Hippocampus (gyrus dentatus) | 13.4 ± 0.9 | 15.1 ± 1.1 | 13.8 ± 0.6 | 46.8 ± 1.9 | 46.2 ± 2.4 | 46.2 ± 3.6 | |
| Lateral septum | 15.2 ± 1.4 | 14.2 ± 1.65 | 15.7 ± 0.7 | 40.1 ± 2.1 | 44.7 ± 0.5 | 44.5 ± 3.3 | |
| Amygdala | 44.4 ± 4.0 | 47.0 ± 1.1 | 48.1 ± 2.8 | 15.5 ± 1.1 | 17.2 ± 1.6 | 15.6 ± 2.0 | |
| Hypothalamus (dorsomedial) | 15.2 ± 1.9 | 16.0 ± 1.6 | 17.8 ± 3.0 | 20.7 ± 1.5 | 15.1 ± 2.6 | 16.7 ± 1.8 | |
Mean ± S.E.M. (n = 5).
↵2-a P < .05 when compared to control group.
2-b P < .05 when compared to SMB(−) group.