Serum biochemical variables in arthritic rats on day 28 postadjuvant. Effect of calcium clodronate after prophylactic and therapeutic treatment. Mean (S.E.M.)
| Group | n | Alkaline Phosphatase (U/l) | Calcium (mmol/l) | Osteocalcin (μg/l) |
|---|---|---|---|---|
| Normal untreated | 5 | 563 (23) | 2.96 (0.04) | 29.7 (1.2) |
| Arthritic control | 10 | 451 (18) | 2.80 (0.03) | 27.3 (0.6) |
| Calcium clodronate prophylactically | 10 | 406 (14) | 2.84 (0.03) | 22.8 (0.5) |
| Calcium clodronate therapeutically | 10 | 477 (21) | 2.91 (0.02) | 22.9 (0.5) |
| Analysis of variance | P | P | P | |
| Group | <.001 | .010 | <.001 | |
| Contrast | ||||
| Normal untr. vs. arthr. control | .001** | .004* | .017 | |
| Normal untr. vs.prophyl. | <.001*** | .019 | <.001*** | |
| Normal untr.vs. therap. | .009 | .33 | <.001*** | |
| Arthr. c.vs. prophyl. | .09 | .42 | <.001*** | |
| Arthr. c.vs. therap. | .31 | .013 | <.001*** | |
| Prophyl.vs. therap. | .009 | .08 | .90 |
Contrasts with Bonferroni adjustment*, ** and ***, significant at the levels .05, .01 and .001, respectively.