Effects of 7-OH-DPAT and amisulpride on dopamine synthesis in the rat brain after blockade of impulse flow
| Drug | Dose (mg/kg i.p.) | Dopa Level (ng/g tissue weight) | |
|---|---|---|---|
| Striatum | Limbic System | ||
| Control | — | 1320 ± 126 | 541 ± 23 |
| (100 ± 10) | (100 ± 4) | ||
| + γ-Hydroxy-bu | 750 | 2866 ± 188 | 622 ± 34 |
| tyrate | (217 ± 14) | (115 ± 6) | |
| + 7-OH-DPAT | 0.0827-a | 1333 ± 94 | 357 ± 21 |
| (101 ± 7) | (66 ± 4) | ||
| + Amisulpride | 5 | 1452 ± 56 | 370 ± 36 |
| (110 ± 4) | (68 ± 6) | ||
| 20 | 2172 ± 305* | 541 ± 63* | |
| (165 ± 23) | (100 ± 12) | ||
| 75 | 2388 ± 239* | 570 ± 57* | |
| (181 ± 6) | (105 ± 11) | ||
Rats received NSD-1015 (100 mg/kg) 90 min after the administration of amisulpride or its vehicle control and were sacrificed 30 min thereafter. γ-Hydroxy-butyric acid was administered 45 min before sacrifice. Data are expressed as the mean and S.E.M. (n= 3–7/group). Dopa levels calculated as a percentage of the corresponding control groups are shown in parentheses.
↵7-a 7-OH-DPAT: 0.082 mg/kg s.c.
* p < .05 vs. the γ-hydroxy-butyrate + 7-OH-DPAT group.