Table 1

Affinity of amisulpride for molecularly identified human dopamine receptor subtypes in vitro

DrugKi (nM)
D2 Receptor FamilyD1Receptor Family
D2D3D4D1D5
Amisulpride2.83.2>1000>1000>1000
Haloperidol0.602.33.8271-a 481-a
Clozapine80230891411-a 2501-a

Studies of radioligand binding to human dopamine receptor subtypes transfected into CHO (D2 receptor family) or Sf9 (D1 receptor family) cells were performed as described in “Materials and Methods”. Data represent the mean of at least two independent experiments performed in duplicate.

  • 1-a , Data taken from Sunahara et al. (1991).