Effects of miscellaneous compounds on the discriminative stimulus effects of dizocilpine or PCP
| Compound | Dose Range | Maximal Dizocilpine Response | Response Rate (% Saline), Maximal Effect |
|---|---|---|---|
| mg/kg | |||
| Dizocilpine discrimination | |||
| Pentobarbital | 1–10 | 2.1% at 5.6 mg/kg | 78.4% at 10 mg/kg |
| NPC 12626 | 10–17 | 22.2% at 17 mg/kg | 66.7% at 17 mg/kg |
| LY 274614 | 1–3 | 8.6% at 3 mg/kg | 54.2% at 3 mg/kg |
| Ifenprodil | 1–10 | 4.0% at 10 mg/kg | 52.2% at 10 mg/kg |
| PCP discrimination | |||
| Pentobarbital | 1–10 | 23.2% at 3 mg/kg | 85.2% at 10 mg/kg |
| NPC 12626 | 10–30 | 27.5% at 30 mg/kg | 54.5% at 30 mg/kg |
| LY 274614 | 1–10 | 1.1% at 3 mg/kg | 88.4% at 10 mg/kg |
| Ifenprodil | 1–10 | 16.5% at 3 mg/kg | 69.8% at 10 mg/kg |