ED50 or [MED] (mg/kg i.p.) | ||||||
---|---|---|---|---|---|---|
Presynaptic Dopamine Receptor Blockade | Postsynaptic Dopamine Receptor Blockade | |||||
Apomorphine-Induced | Apomorphine-Induced | d-Amphetamine-Induced | ||||
Yawning | Hypomotility | Hypermotility | Stereotypies | Hypermotility | Stereotypies | |
Amisulpride | 0.19 (2.15–0.23) | [0.3] | [30] | 115 (ND) | [3] | >100 |
Remoxipride | 0.21 (0.04–2.8) | [0.3] | [3] | 3.1 (2.3–4.0) | [3] | 5.6 (4.2–8.2) |
Haloperidol | 0.08 (ND) | Inactive up to 0.2 | [0.15] | 0.2 (ND) | [0.1] | 0.1 (ND) |
ED50 values with 95% confidence limits (in parentheses) were calculated using log probit analysis determined from dose-response curves represented in figures 6, 7, 3, 5, 4 and 5.
ND: The dose-response curve did not fit the regression analysis with 95% confidence limits.