Table 1

Effects of (+)MK-801 on MPP+ levels in the mouse VME

Treatment1.5 hr*8 hr**
(ng/mg protein)
MPTP204.5  ± 59.816.7  ± 5.6
(+) MK-801 + MPTP207.4  ± 24.161.7  ± 9.4
  • * (+)MK-801 (1 mg/kg i.p.) or saline was given 30 min before the administration of MPTP (40 mg/kg s.c.), and the animals were killed at 1.5 hr after MPTP. ** Two injections of (+)MK-801 were given at 4-hr intervals; MPTP was administered 30 min after the first injection, and the mice were killed at 8 hr after the MPTP. Data represent means ± S.E.M.  Statistically different (P < .001) as compared with the value obtained with MPTP alone.