Table 1

The primary structure, molecular weight (MW), isoelectric point (pI) and capacity factor (k′) of the synthetic basic peptides^1-a

Peptide	Primary Structure	MW	pI	k′
Mother compounds
E-2078	H-MeTyr-Gly-Gly-Phe-Leu-Arg-MeArg-d-Leu-NHEt	1035
Ebiratide	H-Met(O₂)-Glu-His-Phe-d-Lys-Phe-NH(CH₂)₈NH₂	997
Tetrapeptide derivatives
001-OH	H-MeTyr-Arg-MeArg-d-Leu-OH	634.8	11.48	1.62
001-EA	H-MeTyr-Arg-MeArg-d-Leu-NHEt	661.8	12.50	1.75
001-C8	H-MeTyr-Arg-MeArg-d-Leu-NH(CH₂)₈NH₂	760.0	12.52	2.93
002-C8	H-MeTyr-Leu-MeArg-d-Leu-NH(CH₂)₈NH₂	718.0	11.82	17.6
003-C8	H-MeTyr-Arg-MeArg-d-Arg-NH(CH₂)₈NH₂	803.0	12.80	0.27
004-C8	H-MeTyr-Leu-d-Leu-d-Leu-NH(CH₂)₈NH₂	660.9	10.88	160
Dipeptide derivatives
101-OH	H-MeTyr-Arg-OH	351.4	10.38	0.08
101-A	H-MeTyr-Arg-NH₂	350.4	11.66	0.30
101-EA	H-MeTyr-Arg-NHEt	378.5	11.66	0.25
101-C2	H-MeTyr-Arg-NH(CH₂)₂NH₂	393.5	11.82	0.10
101-C5	H-MeTyr-Arg-NH(CH₂)₅NH₂	435.6	11.82	0.27
101-C8	H-MeTyr-Arg-NH(CH₂)₈NH₂	477.7	11.82	0.47

↵1-a Isoelectric point and capacity factor, used as measures of basicity and lipophilicity, respectively, of each peptide, were determined as described in “Materials and Methods.”