hα2β2 | hα2β4 | hα3β2 | hα3β4 | hα4β2 | hα4β4 | hα7 | |
---|---|---|---|---|---|---|---|
DHβE2-a | |||||||
K b mean2-b | 0.85 μM | 3.61 μM | 1.62 μM | 13.77 μM | 0.11 μM | 0.01 μM | 19.59 μM |
(−S.D., +S.D.)2-b | (0.78, 0.93) | (1.65, 7.90) | (0.89, 2.94) | (11.34, 16.73) | (0.09, 0.14) | (0.01, 0.04) | (11.1, 34.57) |
nH (mean ± S.E.M.) | 0.94 ± 0.09 | 0.99 ± 0.12 | 1.33 ± 0.26 | 0.94 ± 0.09 | 0.58 ± 0.05 | 0.88 ± 0.10 | 1.12 ± 0.11 |
(N) | (3) | (4) | (5) | (4) | (4) | (5) | (3) |
d-Tubo2-a | |||||||
K bmean2-b | 1.36 μM2-c | 4.24 μM | 2.41 μM | 2.24 μM2-c | 3.16 μM2-d | 0.21 μM2-d | 3.10 μM2-d |
(−S.D., +S.D.)2-b | (1.98, 9.09) | (1.89, 3.09) | (2.43, 4.13) | (0.07, 0.64) | (1.67, 5.75) | ||
nH (mean ± S.E.M.) | 0.682-c | 0.81 ± 0.09 | 1.09 ± 0.14 | 1.032-c | 0.74 ± 0.04 | 0.95 ± 0.11 | 1.69 ± 0.30 |
(N) | (5) | (6) | (5) | (4) | (4) | (3) | (6) |
↵2-a The agonist and dose used for each hnAChRs subunit combination are indicated in the text.
↵2-b Geometric mean values (see “Methods”).
↵2-c A different group of oocytes was tested with each antagonist dose, and therefore, only one curve was fitted to the (averaged) data points (see “Methods”).
↵2-d The difference in potency between d-Tubo and DHβE was statistically significant (P < .01).