Effect of flow rate on 4MU metabolite formation across the intestine and liver5-a
| Perfusate Flow Rate (Q) | ||
|---|---|---|
| 8 ml/min | 10 ml/min | |
| 4MU input rate to intestine (dpm/min) | 1,943,000 ± 642,000 | 2,423,000 ± 737,000 |
| Extraction ratio (E tot)5-b | 0.98 ± 0.004 | 0.97 ± 0.004 |
| Availability (F tot)5-c | 0.02 ± 0.004 | 0.03 ± 0.005 |
| Metabolite formation rate5-d(% 4MU input rate to the intestine) | ||
| 4MUS | 53 ± 5 | 56 ± 4 |
| 4MUG | 45 ± 5 | 42 ± 4* |
| Sum: 4MUS + 4MUG | 98 ± 0.4 | 97 ± 0.4 |
| Recovery5-e(%) | 101 ± 0.7 | 100 ± 0.2 |
↵5-a Steady-state data were expressed as mean ± S.D. of six experiments.
↵5-b Equation 7.
↵5-c Equation 8.
↵5-d Equation 11.
↵5-e Sum of total hepatic venous outflow rate, biliary excretion rate and luminal outflow rate of 4MUS, 4MUG and 4MU divided by the input rate of 4MU to the intestine, QC SMA.
* Data were significantly different from those at 8 ml/min; P < .05.