Perfusate Flow Rate (Q) | ||
---|---|---|
8 ml/min | 10 ml/min | |
4MU input rate to intestine (dpm/min) | 1,943,000 ± 642,000 | 2,423,000 ± 737,000 |
Extraction ratio (E _{tot})^{5-b} | 0.98 ± 0.004 | 0.97 ± 0.004 |
Availability (F _{tot})^{5-c} | 0.02 ± 0.004 | 0.03 ± 0.005 |
Metabolite formation rate^{5-d}(% 4MU input rate to the intestine) | ||
4MUS | 53 ± 5 | 56 ± 4 |
4MUG | 45 ± 5 | 42 ± 4^{*} |
Sum: 4MUS + 4MUG | 98 ± 0.4 | 97 ± 0.4 |
Recovery^{5-e}(%) | 101 ± 0.7 | 100 ± 0.2 |
↵5-a Steady-state data were expressed as mean ± S.D. of six experiments.
↵5-b Equation 7.
↵5-c Equation 8.
↵5-d Equation 11.
↵5-e Sum of total hepatic venous outflow rate, biliary excretion rate and luminal outflow rate of 4MUS, 4MUG and 4MU divided by the input rate of 4MU to the intestine, QC _{SMA}.
* Data were significantly different from those at 8 ml/min; P < .05.