Kinetics and steady-state parameters of the response to ISO or to SALB of 1 μM or 3 μM CARB-preconstricted guinea pig trachea segments
| Parameters1-a | ISO | SALB | ||
|---|---|---|---|---|
| 130 nM1-b (n = 30) | 10 μM1-c(n = 26) | 200 nM1-b (n = 27) | 10 μM1-c (n = 25) | |
| k 1(sec−1) | 101 ± 37 × 10−4 | 189 ± 69 × 10−4 1-d | 97 ± 55 × 10−4 | 281 ± 104 × 10−4 1-e |
| k 2 (sec−1) | 7.8 ± 4.5 × 10−4 | 8.9 ± 4.3 × 10−4 | 29 ± 27 × 10−4 1-d | 39 ± 12 × 10−4 e,f |
| k 3(sec−1) | 2.5 ± 1.6 × 10−4 | 7.1 ± 3.1 × 10−4 1-d | 17 ± 11 × 10−4 1-d | 12 ± 7 × 10−4 1-f |
| Rmax (g) | 3.03 ± 0.47 | 4.40 ± 1.081-d | 1.18 ± 0.501-d | 2.72 ± 0.881-e , 1-f |
| Tmax (g) | 2.55 ± 0.80 | 3.34 ± 0.97 | 1.74 ± 0.67 | 3.48 ± 1.02 |
| Rss (g) | 0.73 ± 0.25 | 1.96 ± 0.811-d | 0.49 ± 0.281-d | 0.63 ± 0.341-f |
| Rmax/Tmax | 1.27 ± 0.35 | 1.37 ± 0.32 | 0.71 ± 0.281-d | 0.82 ± 0.311-f |
| Rss/Rmax | 0.24 ± 0.08 | 0.45 ± 0.16 | 0.43 ± 0.18 | 0.24 ± 0.11 |
Shown are mean values ± S.D. observed in the indicated number of segments from eight animals.
↵1-a See “” and Figure 1 for definitions of terms.
↵1-b Guinea pig trachea segments preconstricted with 1 μM CARB.
↵1-c Guinea pig trachea segments preconstricted with 3 μM CARB.
↵1-d The significance of the differences between the elements of each row was tested by means of the Kruskal-Wallis H test, P < .05 vs. 130 nM ISO.
↵1-e P < .05 vs. 200 nM SALB.
↵1-f P < .05 vs. 10 μM ISO.